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GENTAUR Europe BVBA Voortstraat 49, 1910 Kampenhout BELGIUM Tel 0032 16 58 90 45 Fax 0032 16 50 90 45 This email address is being protected from spambots. You need JavaScript enabled to view it.">This email address is being protected from spambots. You need JavaScript enabled to view it. |
GENTAUR BULGARIA
53 Iskar Str. 1191 Kokalyane, Sofia
Tel 0035924682280
Fax 0035929830072
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GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50
Fax 01 43 25 01 60
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GmbH Marienbongard 20
52062 Aachen Deutschland
Tel (+49) 0241 56 00 99 68
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GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531
Fax 020 8445 9411
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GENTAUR Poland Sp. z o.o.
ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
Tel 058 710 33 44
Fax 058 710 33 48
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GENTAUR Nederland BV
Kuiper 1
5521 DG Eersel Nederland
Tel 0208-080893
Fax 0497-517897
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GENTAUR SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6, 24122 Bergamo
Tel 02 36 00 65 93
Fax 02 36 00 65 94
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GENTAUR Spain
Tel 0911876558
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Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
Phone/Fax:
(408) 780-0908
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GENPRICE Inc. invoicing/ accounting:
6017 Snell Ave, Suite 357
San Jose, CA. 96123
Serbia, Macedonia,
Montenegro, Croatia:
Tel 0035929830070
Fax 0035929830072
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GENTAUR Romania
Tel 0035929830070
Fax 0035929830072
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GENTAUR Greece
Tel 00302111768494
Fax 0032 16 50 90 45
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Other countries
Luxembourg +35220880274
Schweiz Züri +41435006251
Danmark +4569918806
Österreich +43720880899
Ceská republika Praha +420246019719
Ireland Dublin +35316526556
Norge Oslo +4721031366
Finland Helsset +358942419041
Sverige Stockholm +46852503438
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iStir Uno/Penta Motorless - Magnetic Stirrer
• Variable speed setting (15 to 1500 rpm) with indicator
• No moving parts – maintenance free long life
• The slimmest Stirrers (12 mm)
• Capacity 800 ml - set up place diameter 100 mm. - suitable for stirrer bar of upto 25 mm length
• Pulse mode feature – changes direction for proper mixing
• Individual control & sync mode option (Penta)
• SS top to fight corrosion and IP 64 complaint design
Price: 320 €
Order: iStir Uno Motorless - Magnetic Stirrer
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iShak Uno/Uno VT Personal Microplate Shaker
•Smallest footprint – just the size of the micro plate
•Even mixing across plate with 2 mm orbital diameter
•Speed range 200 to 1500 rpm (Max 1500 rpm)
• 2 versions: Variable Speed and Speed & Time setting version
• Changeable clamps to suit different types of plates
• Inbuilt counter balance for stable operation
•Remote operation (via USB) & data logger (VT)
• Universal Power supply (100 t0 240 VAC, 50/60 Hz)
• Dimensions: 127 x 85 x 86 mm – Weight : 1.4 kg
Price: 300 / 319 €
Order: iShak Uno Personal Microplate Shaker / iShak Uno VT Personal Microplate Shaker
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iFuge M12P High Speed Micro Centrifuge, Table Top Genius
|
Specifications |
iFuge M12P |
Rotor Capacity |
12 place Closed Rotor with Metal safety Lid |
Maximum RPM/RCF |
15000/15596g |
Display |
Larg back-lit LCD disply |
Imbalance Detection |
Adjustable Imbalance Detection With auto cut off |
Noise Level |
< 60 db |
Motor Type |
(BLDC) Brushless DC motor |
Remote Operation |
Yes,Operte & Save logs by connecting to computer |
Time Setting |
1-999 Mins Timer |
Dimensions (WxDxH) in mm |
230 x 262 x 131 |
Rotors and Adaptors (included in standard pack) |
12place x 1.5/2.0ml |
|
Reduction adaptors For 0.2ml microtubes |
|
Reduction adaptors For 0.4/0.5ml microtubes |
|
PCR Strip Rotor (2x8x0.2 ml With Metal safety lid) |
Optinal Rotors |
- |
Download ebrochure for M12/M18P
Price: 833 €
Order: iFuge M12P
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iFuge BL08VT Smart BLDC Personal Micro Centrifuge
• Max Speed 6000 rpm (2000 x g) & Max Cap. 8 x 2 ml
•Brushless motor drive or maintenance free long life
• Self correcting closed loop control – delivers accuracy of +/- 10 rpm at even at varying loads
• Closed rotor design provides better airflow for efficient noiseless operation an less heating
• Sensor based imbalance detection (VT)
• Variable Speed and Time setting feature (VT)
• Next gen design with Digital Display
• Robust lid and hinge design to last long with frequent usage (spin downs)
Price: 339 €
Order: iFuge BL08VT Smart BLDC Personal Micro Centrifuge
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iFuge M08VT Smart Personal Centrifuge
|
Specifications |
iFuge M08VT |
Rotor Capacity |
8 Place Closed Rotor for 1.5/2.0 ml microtubes |
Maximum RPM/RCF(g) |
6000/2000g |
Display |
Digital Display |
Imbalance Detection |
Yes |
Noise Level |
< 55 db |
Variable Speed |
Yes(1000-6000 RPM In Steps of 100 RPM) |
Time |
1-25 Minutes & infinite mode |
Dimensions (WxDxH) in mm |
162 x 157 x 115 |
Rotors and Adaptors (included in standard pack) |
8 Slot x 1.5/2.0 ml Closed Rotor |
|
PCR Strip Rotor (2 x 8 x 0.2 ml) |
|
Reduction Adaptors for 0.2 / 0.4 ml Microtubes |
Download ebrochure for M08/M08VT
Price: 313 €
Order: iFuge M08VT centrifuge
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iFuge M08 Personal Micro Centrifuge
* Special speed version between 1000 RPM to 6000 RPM can be provided on request |
Specifications |
iFuge M08 |
Rotor Capacity |
8 Place Closed Rotor for 1.5/2.0 ml microtubes |
Maximum RPM/RCF(g) |
6000/2000g |
Display |
Digital Display |
Imbalance Detection |
No |
Noise Level |
< 55 db |
Variable Speed |
- |
Time |
1-25 Minutes & infinite mode |
Dimensions (WxDxH) in mm |
162 x 157 x 115 |
Rotors and Adaptors (included in standard pack) |
8 Slot x 1.5/2.0 ml Closed Rotor |
|
PCR Strip Rotor (2 x 8 x 0.2 ml) |
|
Reduction Adaptors for 0.2 / 0.4 ml Microtubes |
Download ebrochure for M08/M08VT
Price: 267 €
Order: iFuge M08 cenrifuge
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Researchers have created embryonic stem cells for 30 minutes
Scientists from the U.S. and Japan have made a breakthrough in stem cell research, finding a cheap and easy way to reprogram adult cells from mice and return them in a state resembling embryonic when cells are able to differentiate into various cell types and tissues.
In other words - the specialists were able to obtain embryonic stem cells without embryos, Reuters, ending up publication in the journal "Nature." The discovery of embryonic stem cells, scientists have high hopes for their use in the treatment of many diseases because of their pluripotency - the ability to develop into different cells and tissues.
The problem with embryonic stem cells is that retrieval means the destruction of the embryo , which raises ethical issues. With the new method, these concerns fall. In 2006, scientists offer an alternative to embryonic cells - ie. induced pluripotent cells. These are normal adult cells back into an undifferentiated pluripotent state through the introduction of foreign genetic material. The problem of induced pluripotent cells , however, is that they can be differentiated only in certain cell types, in contrast to embryonic, which are able to develop into any cell type.
Now the authors of this study - specialists from Japan Institute for physico-chemical studies and their colleagues from the hospital "Brigham end uimins" in Boston and Harvard Medical School in the U.S. have demonstrated that any mature adult cell (somatic cell) has the potential to become equivalent of embryonic stem cells.
Scientists have demonstrated in preclinical models of innovative and unique way to reprogram adult cells that does not require the introduction of foreign DNA - a process used in induced pluripotent stem cells.
In the experiments specialists left mature adult cells to multiply , then they are stressed to near the limit, exposing them to different stress factors - trauma, limited oxygen, acidic environment. Scientists have found that within days the cells survived and recovered from stressful stimuls, returning naturally to a state similar to that of embryonic stem cells.
Thus obtained cells called STAP (Stimulus-triggered acquisition of pluripotency - acquired under the influence of incentives pluripotency) cells were able to differentiate and develop into different cell types and tissues depending on the conditions in which placed.
Scientists find groovy way to influence specialization of stem cells
The primary cilia were grown on micro-grooves 10 micrometres in size
Stem cells are capable of becoming any cell type within the body through the process of differentiation.
The discovery has the potential for application in the development of new therapies for a range of medical treatments where scientists aim to replace or regenerate tissues that have become diseased or dysfunctional.
Publishing in the journal Scientific Reports, the researchers found that growing adult stem cells on micro-grooved surfaces disrupts the biochemical pathway that determines the length of the primary cilia. This change in length of the structure ultimately controls the subsequent behaviour of the stem cells.
"Primary cilia are a thousand times smaller than the width of a human hair and are a ubiquitous feature of most cell types but were once thought to be irrelevant. However, our research shows that they play a key role in stem cell differentiation," explains co-author Professor Martin Knight from Queen Mary's School of Engineering and Materials Science and the Institute of Bioengineering.
"We found it's possible to control stem cell specialization by manipulating primary cilia elongation, and that this occurs when stem cells are grown on these special grooved surfaces."
Stem cells are being considered to treat a number of degenerative conditions such as arthritis, Alzheimer's disease and Parkinson's disease.
A digital test for toxic genes
Like little factories, cells metabolize raw materials and convert them into chemical compounds. Biotechnologists take advantage of this ability, using microorganisms to produce pharmaceuticals and biofuels. To boost output to an industrial scale and create new types of chemicals, biotechnologists manipulate the microorganisms' natural metabolism, often by "overexpressing" certain genes in the cell. But such metabolic engineering is hampered by the fact that many genes become toxic to the cell when overexpressed.
Now, Allon Wagner, Uri Gophna, and Eytan Ruppin of Tel Aviv University's Blavatnik School of Computer Science and Department of Molecular Microbiology and Biotechnology, along with researchers at the Weizmann Institute of Science, have developed a computer algorithm that predicts which metabolic genes are lethal to cells when overexpressed. The findings, published in Proceedings of the National Academy of Sciences, could help guide metabolic engineering to produce new chemicals in more cost-effective ways.
"In the lab, biotechnologists often determine which genes can be overexpressed using trial and error," said Wagner. "We can save them a lot of time and money by ruling out certain possibilities and highlighting other, more promising ones."
Gaining an EDGE
When metabolic genes are expressed, the genetic information they contain is converted into proteins, which catalyze the chemical reactions necessary for life. Overexpression means that greater-than-normal amounts of proteins are produced. Biotechnologists typically overexpress native genes of an industrial microorganism to boost a certain metabolic pathway in the cell, thus increasing the production of desired compounds. Sometimes they overexpress foreign genes—genes transferred from other organisms—in an industrial microbe to build new metabolic pathways and allow it to synthesize new compounds. But they often find that their efforts are hindered by the toxicity of the genes that they wish to overexpress.
Prof. Ruppin's laboratory builds large-scale software models of cellular metabolism, one of the most fundamental aspects of life. These models convert physical, chemical, and biological information into a set of mathematical equations, allowing scientists to learn how cells work and explore what happens if they are tweaked in certain ways. The newly developed algorithm, Expression Dependent Gene Effects, or EDGE, predicts what happens if scientists manipulate cells to overexpress certain genes. EDGE allows biotechnologists to foresee cases in which the overexpressed genes become toxic and then direct their efforts toward other genes.
To validate their method, TAU researchers used genetic manipulation tools to overexpress 26 different genes in E. coli bacterial cells. Comparing the results of their computer simulations with the actual growth of the overexpressed strains that was measured in the lab, they saw that EDGE was able to predict which of the overexpressed genes turned out to be lethal to E. coli. EDGE was also successful in identifying cases of foreign genes that were toxic to E. coli, as the researchers learned from comparing the simulations' results with data collected by their collaborators at the Weizmann Institute of Science.
Beyond bacteria
EDGE's applications appear to extend beyond bacteria. The researchers conducted tests showing that the genes EDGE predicted to be toxic when overexpressed are expressed at low levels not only in microorganisms like bacteria, but also in multicellular organisms, including humans. The researchers say these results reflect the vital evolutionary need to keep the expression of potentially deleterious genes in check.
"Although EDGE's current focus is biotechnology, gene overexpression also plays a central part in many human diseases, particularly in cancer. We hope that future work will apply EDGE to those directions," Wagner said.
Amino acid acts as a substitute for aspirin
Many people take prophylactic aspirin for fear that it may get blood clots and thus lead to a stroke or heart attack. Acetylsalicylic acid, however, can cause unpleasant symptoms in digestive tract. According to some specialists substance arginine can easily replace it. However, they recognize that further studies.
Narrowed blood vessels, high blood pressure and problems with blood flow in the heart sick . It is as a pump, which in this case is a system overload. Atherosclerosis begins with small deposits on the inner walls of blood vessels. Thus, the so-called endothelium of the arteries deteriorate functional change that occurs well before the appearance of the typical plate and before the diagnosis of atherosclerosis have been possible. When the plate reaches a certain density, leading to problems with blood supply - there may be pain when walking, problems with concentration, dizziness and tightness in the chest . In the worst case, forming clots that clog a court. The consequence is a stroke or heart attack.
Dangerous of atherosclerosis is that it occurs silently and imperceptibly. No pain, and symptoms occur when it is already too late. To prevent this process, many people take preparations to thin the blood. Acetylsalicylic acid is the most popular of them. There are a lot of scientific evidence that it prevents clumping of cells in the blood, improves circulation and is therefore considered as the prevention of heart attacks.
Taking aspirin also has minuses - many people with sensitive stomachs do not tolerate it. Other side effects include heartburn, nausea, vomiting, stomach pain and diarrhea.
Scientists now have the first data that the amino acid arginine can be used as a substitute of acetylsalicylic acid in the dilution of the blood. It is found in some natural products such as red meat, wheat germ, soybeans, shrimp and nuts. It is found as a dietary supplement. Arginine has a positive effect on the cardiovascular system, it is considered a natural aphrodisiac.
Substance degree before important for body nitrogen monoxide (NO). It dilates blood vessels, improves blood flow, thus contributing to the decline in blood pressure. Nitrogen monoxide normalized functional disturbances in the inner wall of the arteries, as in atherosclerosis it is not formed in a sufficient amount in the vessel wall.
Arginine enhances not only the viscosity of the blood. Survey Prof. A. Saleh from Cairo University found that this amino acid can prevent clotting and the formation of plaque on the inner walls of the arteries as well as acetylsalicylic acid. The title, however, is the first study of its kind and its results can not yet be used for general reference.