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 GENTAUR Europe BVBAVoortstraat 49, 1910 Kampenhout BELGIUM Tel 0032 16 58 90 45 Fax 0032 16 50 90 45 This email address is being protected from spambots. You need JavaScript enabled to view it.">This email address is being protected from spambots. You need JavaScript enabled to view it. |
GENTAUR BULGARIA
53 Iskar Str. 1191 Kokalyane, Sofia
Tel 0035924682280
Fax 0035929830072
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GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50
Fax 01 43 25 01 60
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GmbH Marienbongard 20
52062 Aachen Deutschland
Tel (+49) 0241 56 00 99 68
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GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531
Fax 020 8445 9411
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GENTAUR Poland Sp. z o.o.
ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
Tel 058 710 33 44
Fax 058 710 33 48
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GENTAUR Nederland BV
Kuiper 1
5521 DG Eersel Nederland
Tel 0208-080893
Fax 0497-517897
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GENTAUR SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6, 24122 Bergamo
Tel 02 36 00 65 93
Fax 02 36 00 65 94
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GENTAUR Spain
Tel 0911876558
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Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
Phone/Fax:
(408) 780-0908
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GENPRICE Inc. invoicing/ accounting:
6017 Snell Ave, Suite 357
San Jose, CA. 96123
Serbia, 
Macedonia,
Montenegro, 
Croatia:
Tel 0035929830070
Fax 0035929830072
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GENTAUR Romania
Tel 0035929830070
Fax 0035929830072
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GENTAUR Greece
Tel 00302111768494
Fax 0032 16 50 90 45
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Other countries
Luxembourg +35220880274
Schweiz Züri +41435006251
Danmark +4569918806
Österreich +43720880899
Ceská republika Praha +420246019719
Ireland Dublin +35316526556
Norge Oslo +4721031366
Finland Helsset +358942419041
Sverige Stockholm +46852503438
Magyarország Budapest +3619980547
Scientists analyze the DNA of Flatworms
For the first time scientists have deciphered the DNA of flat worms, which may reveal new therapeutic targets for future drugs. The genome is a new resource and the path to faster development of new drugs are urgently needed - flat worms cause two of the seventeen "neglected" tropical diseases listed by the World Health Organization - echinococcosis and cysticercosis.
The research team determined the DNA sequence of the four types of tapeworms to better study the biology and genetics of intestinal parasites. In most species, adults cause few complaints while in the intestines. The larvae, however, can cause serious medical complications in moving their body. They form cysts in the bodies of humans and animals, which can lead to complications such as blindness or epilepsy.
According to Dr. Matthew Beriman of the Wellcome Trust Sanger Institute, parasitosis of flat worms are widespread. Their global burden is comparable to that of multiple sclerosis and melanoma.
Typically, the researchers analyzed the DNA of pathogens and compare it with that of man, and thus identify potential targets for future drugs. In this study, however, researchers are mainly interested in the similarities in the DNA of human intestinal parasites. This is because unlike most pathogens such as bacteria and viruses, flat worms are eukaryotic organisms like humans. Flatworms much more like a human structure and physiology of any bacteria or virus.
Furthermore, by analyzing the similarities between the genomes, researchers discovered which of already existing drugs might be effective against parasites. This can save hundreds of decades of work and millions of dollars in investments.
It turns out that some tapeworms are sensitive to the drugs currently used to treat cancer. Another potential solution is cholesterol lowering medication. In the course of evolution, flat worms have lost the ability to synthesize their own cholesterol, which obtain at the expense of the host. Promising target for new drugs are proteins, through which the larvae absorb cholesterol from the intestine. If the function of these proteins has been crossed, the larvae will stop development and will die.
