The p40 antibody, catalog number A00112 is provided in concentrated form or in ready-to-use as a 2ml, 7ml, or 25ml.  This antibody is very important as it is helpful in the indication of several different carcinomas and has a wide-spread use in the market.  We have developed the p40 antibody as a replacement antibody for the p63 antibody.  The marker is highly specific for squamous basal cells and is more specific than the p63 marker.  One of the most important functions of this antibody is the ability to differentiate between adeno carcinoma and squamous cell carcinoma for lung cancer.  As you are aware the difference between those carcinomas will determine what avenue of treatment will be applied.  The p40 is specific for indication of the squamous cell carcinoma.  We will soon be releasing our Napsin A antibody for the adeno carcinoma.  These two antibodies work well in conjunction with one another and they will help the pathologist determine what method of treatment is necessary.

The p40 is also an excellent antibody in the use of prostate cancer.  In the early stages of prostate cancer the basal cells inside the ducts will be stained by the p40.  This will help indicate the prostatic intraepithelial neoplasia (PIN) that is considered to be a pre-malignancy as it is a carcinoma in situ of the prostatic glands.  As the cancer progresses the basal cells will be seen throughout the tissue as the cells become invasive.  This antibody can help determine the stage of carcinoma by indicating locations of the basal cells that are stained.

The p40 antibody is also being used with breast cancer as the antibody will stain myoepithelial cells along the ducts of the mammary glands.  This antibody is excellent in determining if Atypical ductal hyperplasia (ADH) is present which can indicate a risk factor for breast cancer and serves as early detection of breast cancer.  This marker will also indicate Ductal Carcinoma in Situ (DCIS) similar to the way it works on prostate cancer.  This is the most common non-invasive type of breast cancer.  The marker will indicate DCIS by highlighting that the cells are still within the ducts.  As breast cancer progresses and becomes invasive those ducts will breakdown and the myoepithelial cells will be seen throughout the tissue and become Invasive Ductal Carcinoma (IDC). 

p40 (p63 Delta); Polyclonal (Ready-To-Use)

Species: Rabbit
Clone: Polyclonal
Isotype: Rabbit IgG
Species Reactivity: Human.
Cellular Localization: Nuclear.
Specificity: The new marker p40 (p63 delta) is highly specific for squamous basal cells.

 Data sheet | MSDS

p40 (p63 Delta); Polyclonal (Concentrate)

Species: Rabbit
Clone: Polyclonal
Isotype: Rabbit IgG
Species Reactivity: Human.
Cellular Localization: Nuclear.
Specificity: The new marker p40 (p63 delta) is highly specific for squamous basal cells.

Data sheet | MSDS