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GENTAUR Europe BVBA Voortstraat 49, 1910 Kampenhout BELGIUM Tel 0032 16 58 90 45 Fax 0032 16 50 90 45 This email address is being protected from spambots. You need JavaScript enabled to view it.">This email address is being protected from spambots. You need JavaScript enabled to view it. |
GENTAUR BULGARIA
53 Iskar Str. 1191 Kokalyane, Sofia
Tel 0035924682280
Fax 0035929830072
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GENTAUR France SARL
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Tel 01 43 25 01 50
Fax 01 43 25 01 60
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GmbH Marienbongard 20
52062 Aachen Deutschland
Tel (+49) 0241 56 00 99 68
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GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531
Fax 020 8445 9411
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GENTAUR Poland Sp. z o.o.
ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
Tel 058 710 33 44
Fax 058 710 33 48
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GENTAUR Nederland BV
Kuiper 1
5521 DG Eersel Nederland
Tel 0208-080893
Fax 0497-517897
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GENTAUR SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6, 24122 Bergamo
Tel 02 36 00 65 93
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Tel 0911876558
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Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
Phone/Fax:
(408) 780-0908
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GENPRICE Inc. invoicing/ accounting:
6017 Snell Ave, Suite 357
San Jose, CA. 96123
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Chemists have created synthetic antibodies for strengthening immunity
Researchers at the Massachusetts Institute of Technology (MIT) and the University of Hanyang (Hanyang University) created a "synthetic antibodies". As a basis chemists have used carbon nanotubes, which fluoresce under laser irradiation.
Previously, this phenomenon has been used by other investigators, the carbon nanotubes are coated with the natural antibodies. When meeting with certain molecules such structures either light or dimmed, so you can use them as a sort of sensors. However, such sensors are destroyed in the living cell, which significantly limits their period of operation.
To solve this problem MIT chemists replaced by antibodies specifically synthesized amphiphilic polymers. These macromolecules contain regions that interact with water (hydrophilic) or push it (hydrophobic).
Polymers synthesized so that their hydrophobic portions fixed firmly on the surface nanotubok as armature, and constitute a hydrophilic "loops", which form a kind of crown around the particle. Loops arranged strictly along the tube, and the distance between anchors determines which target molecule can hook into the loop and change the nanotube fluorescence.
The uniqueness of this new approach is that before the polymer is attached to the nanotube is impossible to predict the possibility of molecular recognition, looking at the structure of the target and the polymer. That is, the polymer itself can not selectively detect a particular molecule.
In his article, published in the journal Nature Nanotechnology, researchers publish a description of molecular sensors, specific for riboflavin (vitamin B2), estradiol (female sex hormone) and L-thyroxine (thyroid hormone).
Currently, scientists are actively developing on certain neurotransmitters, carbohydrates and proteins. Another important challenge for the research team is to understand exactly what is happening with the polymer and nanoparticle throughout the whole capture specific target molecule.
The researchers believe that their current and future developments in the field of molecular recognition will open huge opportunities for monitoring of diseases such as cancer, multiple inflammations, diabetes and many others in any living organism.