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GENTAUR Europe

 GENTAUR Europe BVBA
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45 
Fax 0032 16 50 90 45
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Gentaur Bulgaria

 GENTAUR BULGARIA
53 Iskar Str. 1191 Kokalyane, Sofia
Tel 0035924682280 
Fax 0035929830072
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    GENTAUR France

     GENTAUR France SARL
    9, rue Lagrange, 75005 Paris 
    Tel 01 43 25 01 50 
    Fax 01 43 25 01 60
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    Gentaur Germany

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      GmbH Marienbongard 20
    52062 Aachen Deutschland
    Tel (+49) 0241 56 00 99 68 
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    Gentaur London

     GENTAUR Ltd. 
    Howard Frank Turnberry House 
    1404-1410 High Road 
    Whetstone London N20 9BH 
    Tel 020 3393 8531 
    Fax 020 8445 9411
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    GENTAUR Poland

     GENTAUR Poland Sp. z o.o. 

    ul. Grunwaldzka 88/A m.2

    81-771 Sopot, Poland
    Tel  058 710 33 44
    Fax 058 710 33 48 
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    GENTAUR Nederland

     GENTAUR Nederland BV
    Kuiper 1 
    5521 DG Eersel Nederland
    Tel 0208-080893 
    Fax 0497-517897
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    Gentaur Italy

     GENTAUR SRL IVA IT03841300167

    Piazza Giacomo Matteotti, 6, 24122 Bergamo
    Tel 02 36 00 65 93 
    Fax 02 36 00 65 94
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    GENTAUR Spain

     GENTAUR Spain
    Tel 0911876558
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    Genprice USA

    usa-flagGenprice Inc, Logistics
    547, Yurok Circle
    San Jose, CA 95123
    Phone/Fax: 

    (408) 780-0908 

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    GENPRICE Inc. invoicing/ accounting:
    6017 Snell Ave, Suite 357
    San Jose, CA. 96123

     

    Gentaur Serbia

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    montenegro-flagMontenegro, croatiaCroatia: 
    Tel 0035929830070 
    Fax 0035929830072
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    GENTAUR Romania

    romGENTAUR Romania

    Tel 0035929830070 
    Fax 0035929830072
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    GENTAUR Greece

    grGENTAUR Greece 

    Tel 00302111768494 
    Fax 0032 16 50 90 45

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    Other countries

    Other countries
    Luxembourg +35220880274
    Schweiz Züri +41435006251
    Danmark +4569918806
    Österreich +43720880899
    Ceská republika Praha +420246019719
    Ireland Dublin +35316526556
    Norge Oslo +4721031366
    Finland Helsset +358942419041
    Sverige Stockholm +46852503438
    Magyarország Budapest +3619980547

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    Displaying items by tag: Gentaur
    Thursday, 25 July 2013 10:34

    Automatic Biochemistry Analyzer 6020

    automatic biochemistry analyzer gentaur 6020System Functions:
    Type:Fully Automated,Random,Access Biochemistry Analyzer
    Throughput:200 tests/hour,up to 280 tests/hour with ISE(optional)
    Test Mode:End point,Kinetics,Fixed time,Immunoturbidimetry
    Monochromatic,Bi-chromatic & Multi-standard Analysis  Linearity & Nonlinearity Calibration
    Single & Dual Reagents can be used.
    Test Setting:Programmable for single-parameter,multi-parameter,combined parameter,batch test
    Test Range:Clinical Biochemistry,Turbidimetry,ISE,Protein,Drug abuse
    Parameter Setting:Completely oper for editing test parameters and calculation parameters
    Sample System:
    Sample Tray:44 sample positions for primary tubes,test tubes and various sample cups
    Whole sample tray can be removed and replaced
    Any position can be aligned as the emergency test position
    Sample Volume:3µl~ 30µl,programmed by 0.1µl step
    Sample Handling:Dilute and retest automatically when sample’s concentration beyong limitation
    Sample probe:Liquid level detection and collision protection
    Probe cleaning:Automatic washing for both inside and outside,carry over <0.1%
    Syringe:High performance syringe,durable and maintenance free
    Optional item:Bar code reader
    Reagent System:
    Reagent tray:44 positions for Single & Dual reagents,reagent positions can be aligned freely
    Refrigeration:Refrigerated reagent compartment,24 hours non-stop cooling with Peltier element maintaining temperature 4~15℃
    Reagent bottle volume:35ml and 20ml,Slope bottom design
    Reagent volume:150µl ~300µl ,programmed by 0.1µl step
    Reagent probe:Automatic liquid level detection function and collision protection
    Reagent pre-heating function,inventory checking
    Real time monitoring of reagent residual volume and auto alarm.
    Probe cleaning: Automatic washing for both inside and outside,carry over 0.1%
    Reaction System
    Reaction tray:48 reaction cuvettes with 6mm optical path,good UV penetrability,low consumable,low cost
    Reaction technology:Back-Dividing-Light Technology
    Reaction volume:250µl ~300µl
    Temperature:37℃,with+ 0.1℃ flutuation
    Mixing system:Independent mixer
    Cleaning:Automatic cuvettes cleaning and complete drainge to reduce carry over
    Water consumption:5L/hour
    Liquid detection:Detergent,distilled water,waste liquid automatic detection and alarm
    Optical System:
    Light source:Halogen lamp 6V/10W,life span≥ 3000hours
    Wavelength:340nm,405nm,450nm,492nm,505nm,546nm,578nm,620nm,670nm,700nm
    Wavelength accuracy:±2nm
    Detector: Photoelectron Diode Array
    Absorbance range:0.000Abs~3.000Abs
    Calibration & Quality Control
    Calibration mode:Linear (one-point,two-point and multi-point),Logit-Log4P,Logit-Log5P,Spline,Exponential,Polynomial,Parabola
    QC rules:Westgard Multi-rule
    QC mode:Intra day & Inter day QC
    Operating System:
    Computer:Windows 2000 System or above
    Data management:Large capacity for results and reaction curves to be displayed,saved and printed
    Report:Edit and print complete reports,format editable,support network printing
    Port:RS-232
    Working Conditions:
    Power:220V±22V,50/60Hz±1Hz
    Power consumption:≤400VA
    Environmental temperature:15℃~30℃
    Humidity: ≤85%
    Dimension:760(L) x 560(W) x1018(H)mm
    Weight:≥85Kgs
     

    Price: 6860 Euro

     
     
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    Published in Promos

    biochemistry analyzer gentaur antibodiesFeatures:

    1. Stream line design, nice appearance

    2. Self calibration and trouble alarm function

    3. Absolutely open system: both of programming and reagent

    4. Warning tone for finished sipping and any other ready function

    5. Function sketches on main menu; the software is simplicity, easy and fast operation.

    6. Real time curve monitoring enhances the reliability of result.

    7. Memory for 100 programs and 20000 test results, results tracking by date.

    8. On-broad Quality control, control results available either memory or display.

     

    Technical Parameters:

    Measuring Mode: Kinetics, End point, Fixed time, Differential, Absorbance,Multi-standard 

    Light source: 6v/10w Halogen Lamp, life Span>3000 hours

    Standard filter: 340nm, 405nm, 505nm, 546nm, 578nm, 620nm, 670nm and one free position.

    Band width: ≤8nm

    Linearity range: 0.000-3.000Abs

    Aspiration volume: 200-1400ul

    Flow cell: 32ul, Optical diameter: 1cm

    Cross contamination rate: ≤1%

    Temperature control: 25℃,30℃,37℃, ±0.1℃ and be controlled by peliter

    Language: English or any language on request

    Output: Built-in printer, RS232 for additional PC

    Display: 240*128LCD

    Power supply: AC220V±10%, 50/60Hz

    Dimension: 430(L) mm×320(W) mm×220(H) mm

    Net weight: 9.0kg

    Price: 1140 Euro

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    Published in Promos
    Wednesday, 24 July 2013 16:48

    Elisa Microplate Reader-SPR960

    elisa microplate reader gentaurAdvanced optical system

    1. 8 channel optical fiber system enables 5 secs' reading for 96 well plate
    2. Auto position function, ensures accurate results
    3. Bichromatic measurement, Multi-calculation methods include ABS, Cut-off , Linearity and Log.
    4. 405nm, 450nm, 492nm, 630nm, 4 free positions

     

    Intelligent software

    1. Big LCD, question and answer mode for program, humanity design, easy to operate
    2. PC controlled, Elisa WorkStation Function
    3. Self-test enables normal condition for any operate
    4. Plate shaking modes editable, enables excellent mixing, giving the reliable results
    5. Multi-test Methods, qualitative and Quantitative Test
    6. Critical value analysis, quantitative analysis, quality control etc
    7. Large storage capacity for 28 test programs
    8. Intelligent Operating software, able to communicate with PC


    Specifications

    1. Plate Type: 96 or 48 well plate or strips
    2. Reading Speed: 5 second for 96 well plate
    3. Light Source: Cold light source
    4. Wavelength Range: 340~750nm
    5. Filters: 405nm, 450nm, 492nm, 630nm, 4 open positions
    6. Linearity range: ±1%(0.000-2.000Abs)
    7. Measure Mode: Monochromatic , Bichromatic
    8. Plate shaking : Time &Speed adjustable
    9. Display: 240*128LCD
    10. Interface: Bi-directional LIS interface for data transfer and handling
    11. Power supply: AC220V/110V±10%,50/60Hz
    12. Dimension: 440(L)mmX305(W)mmX154(H)mm
    13. Net weight: 7kg

    Price: 1400 Euro

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    Published in Promos
    Wednesday, 24 July 2013 16:07

    Microplate Washer SAR-520B

    microplate washer gentaurFeatures:

    Flexible and easy to use

    1. Large and high brightness LCD display, intelligent software, easy to operate

    2. Pre-washing function to avoid tubes plugging

    3. Self calibration and trouble alarm function

    4. New protection design,no liquid spilling

    5. Two groups of needles on washing head to minimize carryover

    6. Large memory to store up to 100 programs  

    7.10different shape plates acceptable

    8. Several washing channels for use

     

    Advanced washing system and intelligent software

    1. Residual volume≤2ul, ensure excellent washing

    2. Flat, U or V-bottom plates and strips washing

    3. Multiple modes for washing, low air bubble

    4. Strong washing function, bottom washing and two positions aspiration make completed washing effect

    5. Automatic monitoring of vacuum and pressure, automatic rinse cycle

    7.8-channel or 12 channels optional

    8. Plate shaking and soaking function, time of speed is adjustable

    9. 5 positions of needles are adjustable, fit for multi-kind of plates

     

    Parameter of SAR-520B Washer:

     

    Plate: 48/96 well and trips (U,V, Flat bottom)

    Residual Volume: ≤2ul

    Dispensing volume: Adjustable from 50 to 900 ul

    Wash cycles:  1-16 optional

    Mode of wash: From 1 to 12, row and rank, selectable

    Soak time:  Up to 990 seconds adjustable

    Shake time: Up to 990 seconds adjustable.

    Display: Large LCD

    Channel: 1 washing channel, one distilled water channel, one waste liquid

    Memory: up to 100 programs can be stored

    Interface: RS232

    Dimension: 440(L) mm×305(W) mm×154 (H) mm

    Net Weight:  7.5kg

    Power Supply: AC220V±10%, 50/60Hz; AC110V±10%, 50/60Hz

     

     

    Price: 1140 Euro

     

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    Published in Promos

    Downs-syndrom-Gentaur-antibodies-chromosome-therapyScientists have corrected the genetic fault that causes Down's syndrome– albeit in isolated cells – raising the prospect of a radical therapy for the disorder.

    In an elegant series of experiments, US researchers took cells from people with DS and silenced the extra chromosome that causes the condition. A treatment based on the work remains a distant hope, but scientists in the field said the feat was the first major step towards a "chromosome therapy" for Down's syndrome.

    "This is a real technical breakthrough. It opens up whole new avenues of research," said Elizabeth Fisher, professor of neurogenetics at UCL, who was not involved in the study. "This is really the first sniff we've had of anything to do with gene therapy for Down's syndrome."

    Around 750 babies are born with DS in Britain each year while globally between one in a 1000 and one in 1100 births are DS babies. Most experience learning difficulties.

    Despite advances in medical care that allow most to live well into middle age, those who have the disorder are at risk of heart defects, bowel and blood disorders, and thyroid problems.

    Though a full treatment is still many years off, the work will drive the search for therapies that improve common symptoms of DS, from immune and gastrointestinal problems, to childhood leukaemia and early-onset dementia.

    "This will accelerate our understanding of the cellular defects in Down's syndrome and whether they can be treated with certain drugs," said Jeanne Lawrence, who led the team at the University of Massachusetts.

    "The long-range possibility – and it's an uncertain possibility – is a chromosome therapy for Down's syndrome. But that is 10 years or more away. I don't want to get people's hopes up."

    In a healthy person, almost every cell in the body carries 23 pairs of chromosomes, which hold nearly all of the genes needed for human life. But glitches in the early embryo can sometimes leave babies with too many chromosomes. Down's syndrome arises when cells have an extra copy of chromosome 21.

    Lawrence's team used "genome editing", a procedure that allows DNA to be cut and pasted, to drop a gene called XIST into the extra chromosome in cells taken from people with Down's syndrome.

    Once in place, the gene caused a buildup of a version of a molecule called RNA, which coated the extra chromosome and ultimately shut it down.

    Previous studies found that the XIST gene is crucial for normal human development. Sex is determined by the combination of X and Y chromosomes a person inherits: men are XY, and women are XX. TheXIST gene sits on the X chromosome, but is only active in women. When it switches on, it silences the second X chromosome.

    Lawrence's work shows that the gene can shut down other chromosomes too, a finding that paves the way for treating a range of other "trisomy" disorders, such as Edward syndrome and Patau syndrome, caused by extra copies of chromosomes 18 and 13 respectively.

    Writing in the journal Nature, the team describes how cells corrected for an extra chromosome 21 grew better, and developed more swiftly into early-stage brain cells. The work, the researchers write, "surmounts the major first step towards potential development of chromosome therapy".

    The work is already helping scientists to tease apart how an extra chromosome 21 causes a raft of problems that strike people with Down's syndrome at various ages. "By the time people with Down's syndrome are in their 60s, about 60% will succumb to dementia. One question is, if we could turn off the extra chromosome in adults, would that stop or ameliorate their dementia?" said Fisher. Another approach would cut the risk of leukaemia by silencing the extra chromosome in bone marrow cells.

    The US team has already begun work that aims to prevent Down's syndrome in mice, by silencing the extra chromosome 21 in early-stage embryos. "That would correct the whole mouse, but it's not really practical in humans," said Lawrence.

    A chromosome therapy for humans would be fraught with practical and ethical difficulties. To prevent Down's syndrome, the genome editing would have to be performed on an embryo or foetus in the womb, and correct most, if not all, of the future child's cells. That is far beyond what is possible, or allowed, today.

     

    Published in News

    kinase antibodies gentaurThe process researchers use to generate induced pluripotent stem cells (iPSCs) -- a special type of stem cell that can be made in the lab from any type of adult cell -- is time consuming and inefficient. To speed things up, researchers at Sanford-Burnham Medical Research Institute (Sanford-Burnham) turned to kinase inhibitors. These chemical compounds block the activity of kinases, enzymes responsible for many aspects of cellular communication, survival, and growth.

    As they outline in a paper published September 25 in Nature Communications, the team found several kinase inhibitors that, when added to starter cells, help generate many more iPSCs than the standard method. This new capability will likely speed up research in many fields, better enabling scientists around the world to study human disease and develop new treatments.

    "Generating iPSCs depends on the regulation of communication networks within cells," explained Tariq Rana, Ph.D., program director in Sanford-Burnham's Sanford Children's Health Research Center and senior author of the study. "So, when you start manipulating which genes are turned on or off in cells to create pluripotent stem cells, you are probably activating a large number of kinases. Since many of these active kinases are likely inhibiting the conversion to iPSCs, it made sense to us that adding inhibitors might lower the barrier."

    According to Tony Hunter, Ph.D., professor in the Molecular and Cell Biology Laboratory at the Salk Institute for Biological Studies and director of the Salk Institute Cancer Center, "The identification of small molecules that improve the efficiency of generating iPSCs is an important step forward in being able to use these cells therapeutically. Tariq Rana's exciting new work has uncovered a class of protein kinase inhibitors that override the normal barriers to efficient iPSC formation, and these inhibitors should prove useful in generating iPSCs from new sources for experimental and ultimately therapeutic purposes." Hunter, a kinase expert, was not involved in this study.

    The promise of iPSCs

    At the moment, the only treatment option available to many heart failure patients is a heart transplant. Looking for a better alternative, many researchers are coaxing stem cells into new heart muscle. In Alzheimer's disease, researchers are also interested in stem cells, using them to reproduce a person's own malfunctioning brain cells in a dish, where they can be used to test therapeutic drugs. But where do these stem cells come from? Since the advent of iPSC technology, the answer in many cases is the lab. Like their embryonic cousins, iPSCs can be used to generate just about any cell type -- heart, brain, or muscle, to name a few -- that can be used to test new therapies or potentially to replace diseased or damaged tissue.

    It sounds simple enough: you start with any type of differentiated cell, such as skin cells, add four molecules that reprogram the cells' genomes, and then try to catch those that successfully revert to unspecialized iPSCs. But the process takes a long time and isn't very efficient -- you can start with thousands of skin cells and end up with just a few iPSCs.

    Inhibiting kinases to make more iPSCs

    Zhonghan Li, a graduate student in Rana's laboratory, took on the task of finding kinase inhibitors that might speed up the iPSC-generating process. Scientists in the Conrad Prebys Center for Chemical Genomics, Sanford-Burnham's drug discovery facility, provided Li with a collection of more than 240 chemical compounds that inhibit kinases. Li painstakingly added them one-by-one to his cells and waited to see what happened. Several kinase inhibitors produced many more iPSCs than the untreated cells -- in some cases too many iPSCs for the tiny dish housing them. The most potent inhibitors targeted three kinases in particular: AurkA, P38, and IP3K.

    Working with the staff in Sanford-Burnham's genomics, bioinformatics, animal modeling, and histology core facilities -- valuable resources and expertise available to all Sanford-Burnham scientists and the scientific community at large -- Rana and Li further confirmed the specificity of their findings and even nailed down the mechanism behind one inhibitor's beneficial actions.

    "We found that manipulating the activity of these kinases can substantially increase cellular reprogramming efficiency," Rana said. "But what's more, we've also provided new insights into the molecular mechanism of reprogramming and revealed new functions for these kinases. We hope these findings will encourage further efforts to screen for small molecules that might prove useful in iPSC-based therapies."

    Published in News
    Monday, 22 July 2013 15:40

    PathoGreen Histofluorescent Stain

    PathoGreen Histofluorescent Stain is an anionic green fluorescent dye functionally similar to Fluoro-Jade dyes. These dyes stain degenerating neurons and their processes after exposure to a variety of neurotoxic insults in brain sections and cultured neurons. The mechanism of neuronal staining by anionic fluorescent dyes has not been determined. It has been proposed that the negatively charged dyes bind to positively charged polyamines or other molecules specifically generated in dying neurons. 

    Download Product Protocol

    Catalog Number :   
        80027-5mL
    Unit Size :   
        5 mL 

     

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    Published in Promos

    Product Description

    Mouse monoclonal antibody to K-bZIP of Herpes Virus Type 8. This antibody originates from ascites fluids and is purified by protein G agarose affinity chromatography.

    Catalog No.

    H8A197

    Unit Size

    500 µg

    Species/Class

    Mouse IgG

    Clone

    F33P1

    Protein Concentration

    1 mg/ml (A280)

    Buffer

    Phosphate Buffered Saline (PBS) pH 7.4

    Purity

    Protein G agarose affinity chromatography

    Functional Activity

    Reactive with SUMOylated and non-SUMOylated species of K-bZIP of Herpes Virus Type 8 in immunofluorescence (IFA) and western blot at 10 µg/ml.

    Shipping & Storage

    This product is supplied frozen on dry ice. Upon receipt, store at -20°C. Avoid multiple freeze-thaw cycles as product degradation may result.

     

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    Published in Promos
    Monday, 22 July 2013 12:58

    Psalmotoxin 1: ASIC1a inhibitor

    Psalmotoxin-1 (PcTx1, Pi-theraphotoxin-Pc1a) has been isolated from the venom of the Spider Psalmopoeus cambridgei (Trinidad chevron tarantula). PcTx1 is known to block potently (IC50 = 1 nM) and selectively the H+-gated sodium channel ASIC1a (acid-sensitive ion channel 1a). The blockage is rapid and reversible. PcTx1 can distinguish between the two ASIC1 splice variants ASIC1a and ASIC1b. PcTx1 loses its capacity to block ASIC1a as soon as this subunit is associated with another member of the family (ASIC2a or ASIC3). PcTx1 demonstrates an analgesic effect in acute and neuropathic pain models.

    PcTx1 technical information

    AA sequence: Glu-Asp-Cys3-Ile-Pro-Lys-Trp-Lys-Gly-Cys10-Val-Asn-Arg-His-Gly-Asp-Cys17-Cys18-Glu-Gly-Leu-Glu-Cys23-Trp-Lys-Arg-Arg-Arg-Ser-Phe-Glu-Val-Cys33-Val-Pro-Lys-Thr-Pro-Lys-Thr
    Disulfide bonds: Cys3-Cys18, Cys10-Cys23 and Cys17-Cys33
    Length (aa): 40
    Formula: C200H312N62O57S6
    Molecular Weight: 4690.82 Da
    Appearance: White lyophilized solid
    Solubility: water and saline buffer
    CAS number: not available
    Source: Synthetic 
    Purity rate: > 98%

    Catalog N° 13PCT001

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    Published in Promos
    Monday, 22 July 2013 12:08

    ADWX-1: Kv1.3 blocker

    ADWX-1 is an optimised synthetic analog of the scorpion peptide BmKTx. ADWX-1 is known to block voltage-gated Kv1.3 channel with a high affinity (IC50 = 1.89 pM) and selectivity (340 fold greater affinity than for voltage-dependent ).ADWX-1 inhibits CD4+ CCR7- T-cell proliferation. ADWX-1 is an interesting therapeutic candidate to treat auto-immune disorders such as multiple sclerosis, type-1 diabetes, rheumatoid arthritis and psoriasis. This peptide is a valuable tool for studying the structure-function of Kv1.3 channel and auto-immunity pathways.

    Product Specifications

    AA sequence: Val-Gly-Ile-Asn-Val-Lys-Cys7-Lys-His-Ser-Arg-Gln-Cys13-Leu-Lys-Pro-Cys17-Lys-Asp-Ala-Gly-Met-Arg-Phe-Gly-Lys-Cys27-Thr-Asn-Gly-Lys-Cys32-His-Cys34-Thr-Pro-Lys-OH
    Disulfide bonds between: Cys7-Cys27, Cys13-Cys32, Cys17-Cys34
    Length (aa): 37
    Formula: C169H281N57O46S7 
    Molecular Weight: 4071.90 Da 
    Purity rate: > 98%
    Appearance: White lyophilized solid
    Solubility: water and saline buffer
    CAS number: not available
    Source: Synthetic

    Catalog N° 13ADW001

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    Published in Promos