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 GENTAUR Europe BVBAVoortstraat 49, 1910 Kampenhout BELGIUM Tel 0032 16 58 90 45 Fax 0032 16 50 90 45 This email address is being protected from spambots. You need JavaScript enabled to view it.">This email address is being protected from spambots. You need JavaScript enabled to view it. |
GENTAUR BULGARIA
53 Iskar Str. 1191 Kokalyane, Sofia
Tel 0035924682280
Fax 0035929830072
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GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50
Fax 01 43 25 01 60
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GmbH Marienbongard 20
52062 Aachen Deutschland
Tel (+49) 0241 56 00 99 68
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GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531
Fax 020 8445 9411
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GENTAUR Poland Sp. z o.o.
ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
Tel 058 710 33 44
Fax 058 710 33 48
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GENTAUR Nederland BV
Kuiper 1
5521 DG Eersel Nederland
Tel 0208-080893
Fax 0497-517897
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GENTAUR SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6, 24122 Bergamo
Tel 02 36 00 65 93
Fax 02 36 00 65 94
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GENTAUR Spain
Tel 0911876558
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Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
Phone/Fax:
(408) 780-0908
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GENPRICE Inc. invoicing/ accounting:
6017 Snell Ave, Suite 357
San Jose, CA. 96123
Serbia, 
Macedonia,
Montenegro, 
Croatia:
Tel 0035929830070
Fax 0035929830072
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GENTAUR Romania
Tel 0035929830070
Fax 0035929830072
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GENTAUR Greece
Tel 00302111768494
Fax 0032 16 50 90 45
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Other countries
Luxembourg +35220880274
Schweiz Züri +41435006251
Danmark +4569918806
Österreich +43720880899
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Ireland Dublin +35316526556
Norge Oslo +4721031366
Finland Helsset +358942419041
Sverige Stockholm +46852503438
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Stress-related protein speeds progression of Alzheimer's disease
Stress protein genetically linked to depression, anxiety and other mental disorders contributes to accelerate Alzheimer chorobyNová study by researchers at the University of South Florida conducted found.
The study is published online today in the Journal of Clinical Investigation.
If the voltage protein FKBP51 cooperates with another protein known as Hsp90 chaperone protein is a huge complex prevents distance from the brain of toxic tau protein associated with Alzheimer's disease.
Under normal circumstances tau helps form the skeleton of our brain cells. USF study was conducted experiments tubes, mice genetically modified to produce abnormal tau protein accumulates in the brains of people with Alzheimer's disease, and Alzheimer's disease post-mortem human brain tissue.
Researchers reported that FKBP51 levels associated with age in the brain, and pakstres protein Hsp90 are with partners to tau more deadly brain cells in memory formation.
JeAsistent Hsp90 protein, which monitors the activity of Tau in nerve cells. Chaperone proteins are generally help to ensure that tau proteins are folded properly maintain healthy structure of nerve cells.
But as FKBP51 levels increase with age, but tear Hsp90 positive impact on the toxicity of tau to promote.
"We found that Hsp90 FKB51 confiscated environment that prevents removal of dew and allows you to create toxic" said the study's principal investigator Chad Dickey, PhD, professor of molecular medicine at the Institute of USF Health Byrd Alzheimer's disease. "Basically, it is used for the production of Hsp90 and to keep the villain."
The authors conclude ževývoj drugs or other ways to reduce FKB51 or block their interaction with Hsp90 as a very significant impact on the treatment of tau pathology in Alzheimer's disease, Parkinson's disease, dementia and other diseases associated with more memory loss.
Earlier studies Dr. Dickey and his colleagues found that a lack of FKBP51 in old mice resistance be improved depressive behavior.
