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 GENTAUR Europe BVBAVoortstraat 49, 1910 Kampenhout BELGIUM Tel 0032 16 58 90 45 Fax 0032 16 50 90 45 This email address is being protected from spambots. You need JavaScript enabled to view it.">This email address is being protected from spambots. You need JavaScript enabled to view it. |
GENTAUR BULGARIA
53 Iskar Str. 1191 Kokalyane, Sofia
Tel 0035924682280
Fax 0035929830072
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GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50
Fax 01 43 25 01 60
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GmbH Marienbongard 20
52062 Aachen Deutschland
Tel (+49) 0241 56 00 99 68
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GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531
Fax 020 8445 9411
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GENTAUR Poland Sp. z o.o.
ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
Tel 058 710 33 44
Fax 058 710 33 48
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GENTAUR Nederland BV
Kuiper 1
5521 DG Eersel Nederland
Tel 0208-080893
Fax 0497-517897
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GENTAUR SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6, 24122 Bergamo
Tel 02 36 00 65 93
Fax 02 36 00 65 94
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GENTAUR Spain
Tel 0911876558
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Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
Phone/Fax:
(408) 780-0908
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GENPRICE Inc. invoicing/ accounting:
6017 Snell Ave, Suite 357
San Jose, CA. 96123
Serbia, 
Macedonia,
Montenegro, 
Croatia:
Tel 0035929830070
Fax 0035929830072
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GENTAUR Romania
Tel 0035929830070
Fax 0035929830072
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GENTAUR Greece
Tel 00302111768494
Fax 0032 16 50 90 45
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Other countries
Luxembourg +35220880274
Schweiz Züri +41435006251
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Ireland Dublin +35316526556
Norge Oslo +4721031366
Finland Helsset +358942419041
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Scientists created the first monoclonal antibodies to fight migraine
At the annual conference of the American Academy of Neurology (AAN), which will be held from April 26 to May 3 in Philadelphia, will be presented to the successful outcome of Phase II clinical trial of two brand new compared to existing drugs for the prevention of migraine attacks, according to a press release AAN. Both drugs are used first for the prevention of migraine monoclonal antibody. The creators promise a new era of medicine in preventive therapy for this disease.
Target against which drugs work, also not previously been involved in order to prevent migraine attacks - monoclonal antibodies block the calcitonin gene-related peptide (CGRP), synthesized by cells of the central and peripheral nervous system neurotransmitter that plays a key role in the transmission of pain.
During the first tests of medicines, ALD403, 163 patients suffering from migraine attacks from five to 14 days per month or one placebo dose. Over the next six months, the group received the drug was observed 66 percent reduction in the number of attacks per month, compared to 52 percent reduction in the group receiving placebo. In 16 percent of the participants received the drug group attacks were completely absent for three months, which was not observed in the placebo group. Difference in side effects between the groups was observed.
In trials of another drug, LY2951742, 217 patients suffering from migraine from 4 to 14 days a month, for three months received twice weekly subcutaneous injections of placebo or drug. In the group receiving therapy, there was a 63 percent reduction in seizure frequency per month compared with a 42 percent decline in the placebo group. In patients receiving the drug were noted side effects such as pain at the injection site, pain in the abdomen and upper respiratory tract infection, but in general medicine was found to be safe and well tolerated.
Although both drugs is still the third phase of clinical trials, according to the representative of the University of California (San Francisco) Godsbi Peter (Peter Goadsby), participated in the creation and testing of both drugs, the results are potentially promising new era in preventive treatment of migraine.
Migraine affects about 14 percent of the adult population and, according to the global health research people on Earth Global Burden of Disease Survey in 2010, is the seventh of disabling diseases.
