GENTAUR Europe BVBA
Genprice Inc, Logistics
Serbia, 
Macedonia, 
Montenegro, 
Croatia: 
GENTAUR Romania
GENTAUR Greece 
Targatt provides a complete range of gene targeting services in rats to generate transgenic knock-in and knock-out rat models.
Rats are more versatile research model animals than mice since they are physiologically more similar to humans. The recent isolation of rat embryonic stem (ES) cells opened the doors to the generation of transgenic rats and we are proud to be one of the first providers of an all-inclusive transgenic rat generation service. Our competence in gene-targeting vector design coupled with our expertise in culturing rat ES cells allows us to offer a high-quality customized service for the generation of transgenic knock-in and knock-out rats.
Using our proprietary germline competent rat ES cell lines we can create your customized transgenic rat model, including
- - Constitutive knockin/out
- - Conditional knockin/out
- - Inducible knockin/out
- - Point mutations
- - Random integration
- - Insertion of reporter genes
- - Humanized rat models
- - Disease rat models
We take great pride in offering you the highest level of service and we are committed to ensuring the success of your transgenic rat project. Our service includes an initial project assessment based on your model requirements. A dedicated PhD level project manager will discuss available gene targeting vector design strategies and will update you continuously throughout the project.
We provide the most flexible customized service options whether you’d like us to do all the work or are on a tight budget and prefer doing some steps yourself.
Full Transgenic Rat Generation Service Includes:
- - Gene targeting vector design, construction and sequencing
- - Rat ES cell targeting, screening and expansion of positive rat ES cell clones
- - Karyotyping of targeted rat ES cells
- - Chimera production via blastcyst injection
- - Chimera breeding for germline transmission
- - Genotyping of offspring
- - Transfer of heterozygous targeted rats to the customer
- - Optional: breeding to generate homozygous rats
All our animals are housed in a facility that is accredited by the Association for Assessment and Accreditation of Laboratory Animal Care (AAALAC) International, has an Assurance on file with the Office of Laboratory Animal Welfare (OLAW), and is a registered research facility with the U.S. Department of Agriculture.
We also offer Knock-in/Knock-out Mouse and Transgenic Mouse (Random Insertion) services. For more information please contact us.
