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GENTAUR Europe

 GENTAUR Europe BVBA
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45 
Fax 0032 16 50 90 45
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Gentaur Bulgaria

 GENTAUR BULGARIA
53 Iskar Str. 1191 Kokalyane, Sofia
Tel 0035924682280 
Fax 0035929830072
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    GENTAUR France

     GENTAUR France SARL
    9, rue Lagrange, 75005 Paris 
    Tel 01 43 25 01 50 
    Fax 01 43 25 01 60
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    Gentaur Germany

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      GmbH Marienbongard 20
    52062 Aachen Deutschland
    Tel (+49) 0241 56 00 99 68 
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    Gentaur London

     GENTAUR Ltd. 
    Howard Frank Turnberry House 
    1404-1410 High Road 
    Whetstone London N20 9BH 
    Tel 020 3393 8531 
    Fax 020 8445 9411
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    GENTAUR Poland

     GENTAUR Poland Sp. z o.o. 

    ul. Grunwaldzka 88/A m.2

    81-771 Sopot, Poland
    Tel  058 710 33 44
    Fax 058 710 33 48 
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     GENTAUR Nederland BV
    Kuiper 1 
    5521 DG Eersel Nederland
    Tel 0208-080893 
    Fax 0497-517897
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    Gentaur Italy

     GENTAUR SRL IVA IT03841300167

    Piazza Giacomo Matteotti, 6, 24122 Bergamo
    Tel 02 36 00 65 93 
    Fax 02 36 00 65 94
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     GENTAUR Spain
    Tel 0911876558
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    Genprice USA

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    547, Yurok Circle
    San Jose, CA 95123
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    (408) 780-0908 

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    San Jose, CA. 96123

     

    Gentaur Serbia

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    Tel 00302111768494 
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    Other countries

    Other countries
    Luxembourg +35220880274
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    Österreich +43720880899
    Ceská republika Praha +420246019719
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    Norge Oslo +4721031366
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    Monday, 11 March 2013 15:15

    Knock-in and Knock-out Rat

    Rate this item
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    Targatt provides a complete range of gene targeting services in rats to generate transgenic knock-in and knock-out rat models.

    Rats are more versatile research model animals than mice since they are physiologically more similar to humans. The recent isolation of rat embryonic stem (ES) cells opened the doors to the generation of transgenic rats and we are proud to be one of the first providers of an all-inclusive transgenic rat generation service. Our competence in gene-targeting vector design coupled with our expertise in culturing rat ES cells allows us to offer a high-quality customized service for the generation of transgenic knock-in and knock-out rats.

    Using our proprietary germline competent rat ES cell lines we can create your customized transgenic rat model, including

    • - Constitutive knockin/out
    • - Conditional knockin/out
    • - Inducible knockin/out
    • - Point mutations
    • - Random integration
    • - Insertion of reporter genes
    • - Humanized rat models
    • - Disease rat models
    • knock-in-knock-out-mouse-targatt-1

     

    We take great pride in offering you the highest level of service and we are committed to ensuring the success of your transgenic rat project. Our service includes an initial project assessment based on your model requirements. A dedicated PhD level project manager will discuss available gene targeting vector design strategies and will update you continuously throughout the project.

    We provide the most flexible customized service options whether you’d like us to do all the work or are on a tight budget and prefer doing some steps yourself.

     Full Transgenic Rat Generation Service Includes:

    • - Gene targeting vector design, construction and sequencing
    • - Rat ES cell targeting, screening and expansion of positive rat ES cell clones
    • - Karyotyping of targeted rat ES cells
    • - Chimera production via blastcyst injection
    • - Chimera breeding for germline transmission
    • - Genotyping of offspring
    • - Transfer of heterozygous targeted rats to the customer
    • - Optional: breeding to generate homozygous rats

     

    All our animals are housed in a facility that is accredited by the Association for Assessment and Accreditation of Laboratory Animal Care (AAALAC) International, has an Assurance on file with the Office of Laboratory Animal Welfare (OLAW), and is a registered research facility with the U.S. Department of Agriculture.

    knock-in-knock-out-mouse-targatt-2

    We also offer Knock-in/Knock-out Mouse and Transgenic Mouse (Random Insertion) services. For more information please contact us.

     

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