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Stress protein genetically linked to depression, anxiety and other mental disorders contributes to accelerate Alzheimer chorobyNová study by researchers at the University of South Florida conducted found.
The study is published online today in the Journal of Clinical Investigation.
If the voltage protein FKBP51 cooperates with another protein known as Hsp90 chaperone protein is a huge complex prevents distance from the brain of toxic tau protein associated with Alzheimer's disease.
Under normal circumstances tau helps form the skeleton of our brain cells. USF study was conducted experiments tubes, mice genetically modified to produce abnormal tau protein accumulates in the brains of people with Alzheimer's disease, and Alzheimer's disease post-mortem human brain tissue.
Researchers reported that FKBP51 levels associated with age in the brain, and pakstres protein Hsp90 are with partners to tau more deadly brain cells in memory formation.
JeAsistent Hsp90 protein, which monitors the activity of Tau in nerve cells. Chaperone proteins are generally help to ensure that tau proteins are folded properly maintain healthy structure of nerve cells.
But as FKBP51 levels increase with age, but tear Hsp90 positive impact on the toxicity of tau to promote.
"We found that Hsp90 FKB51 confiscated environment that prevents removal of dew and allows you to create toxic" said the study's principal investigator Chad Dickey, PhD, professor of molecular medicine at the Institute of USF Health Byrd Alzheimer's disease. "Basically, it is used for the production of Hsp90 and to keep the villain."
The authors conclude ževývoj drugs or other ways to reduce FKB51 or block their interaction with Hsp90 as a very significant impact on the treatment of tau pathology in Alzheimer's disease, Parkinson's disease, dementia and other diseases associated with more memory loss.
Earlier studies Dr. Dickey and his colleagues found that a lack of FKBP51 in old mice resistance be improved depressive behavior.
