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    Monday, 22 July 2013 12:58

    Psalmotoxin 1: ASIC1a inhibitor

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    Psalmotoxin-1 (PcTx1, Pi-theraphotoxin-Pc1a) has been isolated from the venom of the Spider Psalmopoeus cambridgei (Trinidad chevron tarantula). PcTx1 is known to block potently (IC50 = 1 nM) and selectively the H+-gated sodium channel ASIC1a (acid-sensitive ion channel 1a). The blockage is rapid and reversible. PcTx1 can distinguish between the two ASIC1 splice variants ASIC1a and ASIC1b. PcTx1 loses its capacity to block ASIC1a as soon as this subunit is associated with another member of the family (ASIC2a or ASIC3). PcTx1 demonstrates an analgesic effect in acute and neuropathic pain models.

    PcTx1 technical information

    AA sequence: Glu-Asp-Cys3-Ile-Pro-Lys-Trp-Lys-Gly-Cys10-Val-Asn-Arg-His-Gly-Asp-Cys17-Cys18-Glu-Gly-Leu-Glu-Cys23-Trp-Lys-Arg-Arg-Arg-Ser-Phe-Glu-Val-Cys33-Val-Pro-Lys-Thr-Pro-Lys-Thr
    Disulfide bonds: Cys3-Cys18, Cys10-Cys23 and Cys17-Cys33
    Length (aa): 40
    Formula: C200H312N62O57S6
    Molecular Weight: 4690.82 Da
    Appearance: White lyophilized solid
    Solubility: water and saline buffer
    CAS number: not available
    Source: Synthetic 
    Purity rate: > 98%

    Catalog N° 13PCT001

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