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    Friday, 12 July 2013 17:41

    Protoxin I (ProTx-I)

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    Protoxin I: properties

    Protoxin I (ProTx I; β-theraphotoxin-Tp1a) is a toxin that was originally isolated from the venom of Thrixopelma pruriens (Peruvian green velvet tarantula). This toxin reversibly inhibits the tetrodotoxin (TTX)-resistant channel Nav1.8 (IC50 = 27 nM) and TTX sensitive Nav channels such Nav1.2, Nav1.5 and Nav1.7 with IC50 values between 50 and 100 nM. Furthermore, ProTx-I shifts the voltage dependence activity of T-type Cav3.1 channels (IC50= 50 nM) without affecting the voltage dependence of inactivation.

    Product Specification

    AA sequence: Glu-Cys2-Arg-Tyr-Trp-Leu-Gly-Gly-Cys9-Ser-Ala-Gly-Gln-Thr-Cys15-Cys16-Lys-His-Leu-Val-Cys21-Ser-Arg-Arg-His-Gly-Trp-Cys28-Val-Trp-Asp-Gly-Thr-Phe-Ser
    Disulfide bridges: Cys2-Cys16, Cys9-Cys21, Cys15-Cys28
    Length (aa): 35
    Formula: C171H245N53O47S6
    Molecular Weight: 3987.50 Da
    Appearance: White lyophilized solid
    Solubility: water or saline buffer
    CAS number: Not available
    Source: Synthetic 
    Purity rate: > 95 %

    Catalog N : 12PTX001

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