Swiss scientists have developed a new protein structure, which may improve the efficacy of drugs. New synthetic amino acid can be used to create entirely new drugs.
 
Development of new and effective drugs is a feat for many researchers. Until now, most drugs based on the basis of amino acid obtained naturally. These include insulin hormone, vancomycin and the like.
 
There are a variety of peptides and proteins, but only 20 different amino acids. They form a unique structure when they are "stacked" together. The synthetic structure created by the Swiss researcher is similar to that of cysteine ​​- sulfuric amino acid. Synthetic however is significantly more efficient.
 
Disease attack appear more and more people. It takes more effective drugs that can handle the increasing resistance. Like the natural chemical structures may create such a new and improved treatment of various diseases.

Cysteine ​​can form a bridge to the cysteine ​​amino acid found in it, thereby creating 3D structure. The new amino acid, however, can form two bridges, when coupled with other similar amino acid cysteine​​.
 
Laboratory tests revealed that the newly synthesized amino acid is eight times more efficient and fight disease by 40-fold higher speed in comparison with a naturally occurring amino acid cysteine.

Treatment of various diseases of the blood and immune system is about to be discovered by scientists that reveal the mystery of the origin of stem cells.
 
Avstraliyskoro study was conducted by the Institute for Regenerative Medicine at Monash University, Melbourne. It first establishes a mechanism that "unlocks" the body in the formation of hematopoietic stem cells (HSC).
 
These cells are found in bone marrow and umbilical cord and are extremely important because they can "feed" the stock of blood cells in the body. Patients with leukemia have been successfully treated with HSC transplantation. Medical experts, however, believe that they can come into wider use.
 
According to the lead researcher - Prof. Peter Curry, understanding the way the HSC is samopodnovyavat to fill blood cells is the "Holy Grail" of stem cell biology.
 
Hematopoietic stem cells are the best therapeutic agent, since they can produce any cell in the body, said Curry, adding that they could be used for the treatment of severe blood diseases. But before that you need to understand how they emerge.
 
During this study, researchers observed cells in the developing zebra fish - tropical freshwater fish known for its regenerative abilities and optically visible embryos.
 
Using a microscope with high resolution scientists capture the manner in which the cells grow. The process of their formation is captured in dramatic detail.
 
Observations found that HSC need a "friendly" type of cell that help their formation. Metaphorically, the researchers explain that these cells serve as a comfortable sofa where HSC accommodate. Researchers establish whether the genes that are required for the formation of these "friendly" cells.
 
The most remarkable achievement of the experts is that they can identify the signals in these cells, helper, which are responsible for the formation of HSC, after which they could be used in vitro for the creation of various blood cells to "fix" all types of diseases related to the blood.

Scientists have discovered a previously unknown virus that lives in the human gut, according to a study published in Nature Communications.
 
An international team of scientists discovered the virus in CrAssphage genetic material from samples of intestine. Scientists believe the virus can affect the behavior of some of the most common bacteria in the intestinal flora.
 
Experts explain that these types of viruses called bacteriophages play an important role in chronic diseases. Leading a team from the State University at San Diego, USA, "clears" the genetic information that is stored in three large international databases.
 
They fall on the portion of the DNA to be detected in more than half of all the samples. Further analysis found that the virus has not been detected so far.
 
Scientists explain that it has a genetic fingerprint of the bacteriophage - type virus, which is known to infect the bacteria. He can control the behavior of bacteria that affect - in some cases makes it easier to live in the environment in which they are located, and may make the bacteria more powerful.
 
Scientists are trying to grow the virus in the laboratory. Explain that the next step will be to establish exactly the way in which the virus affects intestinal bacteria.

• Color Chart for visual reading besides digital
• No interference wirh Ascorbic Acid for Blood & Glucose Tests.
• Light Weight & handy Container

See: Uricha - URINE Chemistry Analyser

Specifications

Uricha is a compact, easy to use urine analyser which mesaures 10 parameters using reflectance photometry principle. 

Features:

• Compact Design and easy to use

• Auto referencing and compensation

• Rapid and High precision

• Built-in printer

• Color chart for visual reading besides digital

• Light weight and Aluminium Cannister with desiccant in the cap

• No interference with Ascorbic acid for Blood and Glucose tests

Technical Specifications:

• Reflectance Photometry principle for measurement

• Optical measurement using RGB Sensor

• Test Parameters : Blood, Urobilinogen, Bilirubin, Protein,

  Nitrite, Ketones, Glucose, pH, Density

  and Leukocytes

• Speed of 50 samples/hour

• Display : 320mm*240mm TFT LCD

• Touch panel human interface

• Built-in Thermal Printer

• Storage memory of 250 results with date

• USB, RS232 Interface to computer

 Download Technical Sheet Specification

Price: 534 €

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See also: Test Strips Compatible With URICHA

Name	Long-term Cell Tracer 580   (Yellow)
Cat. #	P710Y   P710YS (Trial size of 10 pmol)
Application	Cell Tracer is for long-term tracing of a wide range of cell types, including cancer cells, Bone marrow stromal cell (BMSC), Peripheral blood mononuclear cell，Endothelial progenitor cell, human/mice mesenchymal stem cells, skin stem cells et al.. This product is for research use only.
Product Size	1 mL, 200 nM
Excitation and Emission	Excitation: 405 nm or 488 nm Emission : 580 nm
Photostability	in vitro  tracing: 12 generations in vivo   tracing: 3 weeks
Description	Cell Tracers are a class of organic fluorescent dots with comparable size and photostability to inorganic quantum dots (QDs) to overcome the limitations of quantum dots (e.g., potential toxicity and compromised fluorescence in presence of ROS) in advanced bio-imaging applications. Upon conjugation with a cell penetrating peptide, Cell Tracer show excellent labeling efficiency to living cells and outperform the current gold standard, inorganic quantum dots cell labeling kits, in long-term in vitro/in vivo cell tracing applications. Stem cell tracing study also suggests that Cell Tracer has no negative effect on mesenchymal stem cell differentiation. The merits of Cell Tracer make them promising alternatives to quantum dot probes, which is of high importance for translational research applications. Additionally, the biocompatible polymeric matrix endows this kind of organic fluorescent dots customized surface functional groups for further modification/conjugation with a variety of biomolecules for specific imaging tasks besides cell tracking. Long term photostability - 3 weekes in vivo High brightness - high signal to noise ratio Different colors - blue, green, yellow, red Low toxicity - no heavy metal elements Customization friendly - can conjugate with desired biomolecules easy to use - only one component
Shipping / Storage	Ship at room temperature. Store at 4℃ (Can be frozen but avoid freeze/thaw cycles.)
Shelf Life	1 months at room temperature. 1 year at 4℃
Manual (protocol)
Component	Cell Tracer 580 one vial of 1 mL
Remarks	The different colors of Cell Tracers allow simultaneously tracing of two different groups of cells to investigate their migration and interaction.

Price: 635 €

Name	Exosome preparation kit for transmission electron microscopy imaging
Cat. #	P130
Application	This kit is for preparation of exosome samples for transmission electron microscopy imaging assay. This product is for research use only.
Product Size	10 reactions
Description	This is an easy-to-use tool helps you to prepare exosome samples for transmission electron microscope imaging, and to get good quality EM images of exosome structure. This kit contains all reagents and material for the experiment. The exosome purity and density is important for TEM assay. We recommend to use our PureExo kits to isolate exosomes before using this kit.
Shipping / Storage	Ship and store at room temperature
Shelf Life	12 months
Manual (protocol)
Component	1. Formvar-carbon coated EM mesh 400 grid X 10 2. Wash buffer (1.5 ml) 3. EM solution (100 µl)
Other required materials	Parafilm Forceps (Dumont No. 5), clean Whatman No. 1 filter paper Transmission electron microscope (TEM)

Transimission Electron Microscopy

image by our kit

Price: 205 €

The mitochondrial electrochemical gradient is often disturbed during apoptosis and can be detected using cationic dyes such as DePsipher™ (5,5’6,6’- tetrachloro-1,1’,3,3’-tetraethylbenz-imidazolylcarbocyanine iodide) or MitoShift™ (tetramethylrhodamine ethyl ester).

Activation of caspases, or cysteinyl proteases, is a necessary event for execution of the apoptotic response.  Some of the caspases are activated early in the apoptotic process and their activation is the first step in a cascade of proteolytic cleavage of key proteins and enzymes, including other caspases and poly (ADP-ribose) polymerase (PARP). Since the substrate specificity of the caspases is high, analysis of  substrate cleavage also provides a useful biochemical marker.

The movement of some members of the Bcl-2 family from the cytoplasm to the mitochondria and the subsequent associations that occur between them and other mitochondrial membrane associated proteins are indicated to be crucial steps in apoptosis.

DNA fragmentation occurs as one of the final stages of cell death and has long been considered a hallmark of apoptosis and one of the defining biochemical events of the pathway. For detection of the DNA fragmentation associated with apoptosis by DNA laddering, the DNA  is isolated and the cleaved fragments are separated by agarose gel electrophoresis. Our Ethidium Bromide DNA Laddering kit provides the necessary reagents for detection of the DNA ladder. 

Utilizing a TUNEL-based assay, a series of kits for the in situ detection of apoptosis with colorimetric and fluorometric options was developed. The TACS® kits are tailored for the detection of DNA fragmentation associated with apoptosis in a variety of cell and tissue types and for analysis by different formats that include microscopy, flow cytometry, and 96 well plates.

Products: anti-cleaved caspase-3, anti-PARP, PARP Apoptosis Assay Kits, Bcl-2 family antibodies, DePsipher™, MitoShift™, PBR Protein, anti-PBR  

Anti-γH2AX antibody, Apoptotic DNA laddering kit, TACS•XL®, TACS® 2TdT,  VasoTACS™, FlowTACS™, TiterTACS™ 96 Well Kit, NeuroTACS™ II, TumorTACS™, CardioTACS™, DermaTACS™ 

Fungal molecule allows to realize the effect of the antibiotic to achieve the cure. It can be the key to suppression of resistance to antibiotics, according to scientists from the University of McMaster, Canada.
 
The emergence of antibiotic resistance, role playing gene  known as NDM-1. The World Health Organization recognizes it as a global threat to human health due to its resistance to some of the most powerful class of antibiotics known as carbapenems.
 
Despite his frightening presence in many bacterial strains, NDM-1 is found in the most common bacteria among people - Escherichia coli - bacteria that causes most infections of the bladder and kidneys. Without antibiotics to "fight" with NDM-1, doctors are helpless.
 
The carbapenem class of drugs are very similar to penicillin, which means that they are used in a variety of unique situations. Researchers worse is that NDM-1 affects many organisms which themselves cause all sorts of "challenging" conditions and now have multi-drug resistance.
 
Before fungal molecule to be detected in the soil in Nova Scotia, Canada, researchers found that NDM-1 requires zinc to "grow." The challenge in them was to find a way to remove zinc safely and without causing the appearance of side effects for the patient. With the discovery of the molecule, known as AMA, this extraction becomes possible.
 
During the laboratory studies, the experts found that it is really effective and allows the antibiotic to act in order to achieve cure. But there is still much work to researchers, pending the development of a "global" solution.

Recently identified gene mutation increases the risk of developing type 2 diabetes tenfold. It was found in the DNA of the population of Greenland.
 
The study by scientists from Copenhagen gives a new perspective on innate predisposition and the real danger of diabetes.
 
Of course, the presence of the mutation TBC1D4, is not confined only within the largest island on the planet. It has already detected among many Europeans suffering from diabetes.
 
Its "arms" consists in the development of insulin resistance in muscle.
 
The discovery allows for harder prevention of diseases and the development of new techniques for treatment.
 
"We know that each of us has his heredity, which, unfortunately, when diabetes is critical. It is not enough to become diabetics. We do not inherit the disease, and the tendency of its manifestation.
 
Our meeting with a number of external factors such as viruses, chemicals, and other stressful situations may trigger a series of autoimmune processes in our body that damage and destroy cells of the pancreas that produce the hormone insulin, "comment the investigators.
 
They point out that diabetes is not a disease, as it causes many damages to the human body.
 
"We can not change our heredity, but we can change our lifestyle.
 
If you take care of your health in time through healthy eating and daily physical activity we can gain skills for coping with stress alone can reduce the likelihood of falling ill from diabetes, "concluded the report by researchers from Copenhagen.