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GENTAUR Europe

 GENTAUR Europe BVBA
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45 
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Gentaur Bulgaria

 GENTAUR BULGARIA
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    GENTAUR France
    Gentaur Germany

      GmbH Marienbongard 20
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    Tel (+49) 0241 56 00 99 68 
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     GENTAUR Ltd. 
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    Tel 020 3393 8531 
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    seal-in-search-symantec

     

     

    Tuesday, 25 February 2014 17:36

    Potential new treatment for sepsis

    treatment for sepsis insulin smallerSepsis is the leading cause of in-hospital death and there is no specific treatment for it. Now, research led by Dr. Qingping Feng of Western University suggests a protein called recombinant human annexin A5 may have therapeutic potential for the treatment of this disease. The paper is published in advance, online in Critical Care Medicine.

    Sepsis is caused by an overwhelming immune response to an existing infection. It's estimated there are 18 million cases annually worldwide. The mortality rate is 30 to 40 per cent for severe sepsis and 40 to 80 per cent for septic shock. Dr. Feng, a professor in the Departments of Physiology and Pharmacology, and Medicine at Western's Schulich School of Medicine & Dentistry and a scientist at Lawson Health Research Institute is particularly interested in how sepsis causes cardiac dysfunction.

    Annexin A5 is a lipid-binding protein produced by cells. Using mice with induced sepsis, Dr. Feng, Dr. Xiangru Lu, and Paul Arnold, MSc, studied the effects of annexin A5 on cardiac function and animal survival.

    "We treated the septic animals and to our surprise we found a dramatic, significant effect in improving cardiac function during sepsis and improved survival rates in the mice," says Dr. Feng. "We also found it helped even if administered hours after the septic infection. This is important because the delayed treatment simulates what usually happens in a clinical setting. The patient often has had sepsis for several hours, or a few days when they seek treatment."

    Annexin A5 is not currently used as a therapeutic agent, but its safety has been tested in humans. It's currently used in imaging studies to identify cells undergoing apoptosis (cell death).

    While this study looked at the heart, Dr. Feng believes annexin A5's beneficial properties could apply to multiple organs including liver, lungs and kidney, all which can all be affected by sepsis.

    Published in News

    profrHuIL4

    Description: Recombinant Human IL-4 produced in E.Coli is a single, non-glycosylated polypeptide chain containing 130 amino acids and having a molecular mass of 15000 Dalton. The rHuIL-4 is purified by proprietary chromatographic techniques.

    Source : E.coli

    Catalog number : 04-GMPhuIL4-50 µg

    Molecular weight : 15 KDa

    Identity : rh IL-4 as measured by Elisa and Western Blot

    Specific activity : > 13.10 6 units/mg compared to NIBSC standard . CT-h4.S cell proliferation assay.

    650 000 IU /vial

    Purity : > 98% as determined by SDS-PAGE and HPLC

    Endotoxin content : < 0.1 EU/ µg of IL-4 (LAL test)

    Host DNA : < 10 pg/ng protein

    Sterility : sterile according to EP Test 2.6.1.

    Stabiliser : contains Trehalose ; no preservative.

    Physical state : freeze-dried

    Stability : 12 months at – 20°C to – 80°C

    3 months after reconstitution with water for injection ( as defined in EP Monograph 0169) when stored at -80°C

    Reconstitution : use 500 µL water for injection in class A environment in order to keep the GMP grade .

    Packaging unit : 50 µg protein (Lowry test)

    GMP

    GENTAUR rh IL-4 is manufactured in full compliance with cGMP in facilities approved by the Belgian Ministry of Health for the production and storage of medicinal products.

    Use: GENTAUR rh IL-4 is not an approved medicinal product and cannot be injected as such to patients.

    FOR EX VIVO CELL CULTURE AND FOR IN VITRO RESEARCH USE ONLY

    PDF-IconDownload Gentaur's GMP Certificate of Analysis And MSDS

    Price: 483 Euro

    Order Button1

    Published in Top Products
    Wednesday, 06 February 2013 12:34

    GMP IL4 50µg -25°C

    Catalog number : 04-GMPhuIL4-50 µg
    Quantity: 50 µg
    Availability: Yes

    Description: Recombinant Human IL-4 produced in E.Coli is a single, non-glycosylated polypeptide chain containing 130 amino acids and having a molecular mass of 15000 Dalton. The rHuIL-4 is purified by proprietary chromatographic techniques.

    Source : E.coli

    Molecular weight : 15 KDa

    Identity : rh IL-4 as measured by Elisa and Western Blot

    Specific activity : > 13.10 units/mg compared to NIBSC  standard . CT-h4.S cell  proliferation assay. 650 000 IU /vial

    Purity : > 98% as determined by SDS-PAGE and HPLC

    Endotoxin content : < 0.1 EU/ µg of IL-4 (LAL test)

    Host DNA : < 10 pg/ng protein

    Sterility : sterile according to EP Test 2.6.1.

    Stabiliser : contains Trehalose  ;  no preservative.

    Physical state : freeze-dried

    Stability : 12 months at – 20°C to – 80°C

    3 months after reconstitution with  water for injection ( as defined in  EP Monograph    0169) when stored at -80°C

    Reconstitution : use 500 µL water for injection in class A environment in order to keep  the GMP grade .

    Packaging unit : 50 µg protein (Lowry test)  

    GMP:

    GENTAUR rh IL-4 is manufactured in full compliance with cGMP in facilities approved by the Belgian Ministry of Health for the production and storage of medicinal products.

    Use: GENTAUR rh IL-4 is not an approved medicinal product and cannot be injected as such to patients.

    FOR EX VIVO CELL CULTURE AND FOR IN VITRO RESEARCH USE ONLY

     Price: 482 EUR

    Order Button1

    Published in Top Products