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    Articles

    NeuroPhore Drug Application System

    NeuroPhore

    - Up to 5 Channels of Iontophoretic or Pneumatic Drug Delivery
    - Modular Design Allows Upgrades in the Future
    - Low Noise & Automatic Current Compensation Circuitry
    - Aids Troubleshooting with Unbalance & Out of Compliance Indicators
    - External or Internal Control of Timing & Ejection Parameters

    In the past few decades, the application of drugs and other dissolved agents from multibarrel electrodes/pipettes has evolved into a practical method of testing their effects on cells or cellular systems. The versatile NeuroPhore BH-2 System is designed to facilitate controlled ejection of fluids from multi-barrel micropipettes. Extracellular ejections of minute volumes can be delivered using up to fi ve pumps in serial or parallel. The ejection schedule for each pump can be independently programmed for sequential or simultaneous output. Ejection cycles can be internally timed, triggered manually, or synchronised to external events. This flexible system allows the use of Iontophoretic Pump Modules, Pneumatic Pump Modules or a combination of both. By interchanging the IP-2 Iontophoretic Pump Module with a PPM-2 Pneumatic Pump Module, the overall system capability can be expanded for simultaneous pressure and iontophoretic injection of drugs from a multibarrel pipette. The NeuroPhore BH-2 System was developed under the guidance of active researchers with extensive experience in iontophoretic techniques. These researchers needed a system to provide precise stimulation and quantitative control for ejection of drugs in their pharmacological studies of drug evoked responses. What emerged was the reliable, accurate, easy to use NeuroPhore BH-2 System that is capable of accommodating high impedance multi-barreled micro-electrode pipettes.

    BH-2 Mainframe Chassis (includes BM-2 Balance Module & MS-2 Power Supply)

    The BH-2 is prewired to accept one balance and control module and up to fi ve iontophoretic/pneumtic pump modules. The BM-2 Balance Module provides automatic current neutralisation as well as independent control of its current pump settings (from 0 - 500nA). The Balance Module includes digital system timing, clock, provisions for electrical and manual cycle start/stop, a single cycle/recycle switch and trigger/gate input terminals to initiate externally controlled eject pumping action of each module. Analogue input for balance or drive with override capability. Analogue output for monitoring of unbalance currents.

    IP-2 Iontophoretic Module

    Each IP-2 module includes controls for precise settings of current magnitude and polarity (retention 0 - 50 nA, ejection 0 - 500 nA. The actual current and polarity being delivered is continuously displayed digitally and can be externally monitored at the analog output terminal. Ejection Timing & Mode Switch